Sunday, September 30, 2012

Common RNA pathway found in ALS and dementia

Common RNA pathway found in ALS and dementia [ Back to EurekAlert! ] Public release date: 30-Sep-2012
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Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego

Two proteins previously found to contribute to ALS, also known as Lou Gehrig's disease, have divergent roles. But a new study, led by researchers at the Department of Cellular and Molecular Medicine at the University of California, San Diego School of Medicine, shows that a common pathway links them.

The discovery reveals a small set of target genes that could be used to measure the health of motor neurons, and provides a useful tool for development of new pharmaceuticals to treat the devastating disorder, which currently has no treatment or cure.

Funded in part by the National Institutes of Health and the California Institute for Regenerative Medicine (CIRM), the study will be published in the advance online edition of Nature Neuroscience on September 30.

ALS is an adult-onset neurodegenerative disorder characterized by premature degeneration of motor neurons, resulting in a progressive, fatal paralysis in patients.

The two proteins that contribute to the disease FUS/TLS and TDP-43 bind to ribonucleic acid (RNA), intermediate molecules that translate genetic information from DNA to proteins. In normal cells, both TDP-43 and FUS/TLS are found in the nucleus where they help maintain proper levels of RNA. In the majority of ALS patients, however, these proteins instead accumulate in the cell's cytoplasm the liquid that separates the nucleus from the outer membrane, and thus are excluded from the nucleus, which prevents them from performing their normal duties.

Since the proteins are in the wrong location in the cell, they are unable to perform their normal function, according to the study's lead authors, Kasey R. Hutt, Clotilde Lagier-Tourenne and Magdalini Polymenidou. "In diseased motor neurons where TDP-43 is cleared from the nucleus and forms cytoplasmic aggregates," the authors wrote, "we saw lower protein levels of three genes regulated by TDP-43 and FUS/TLS. We predicted that this, based on our mouse studies, and found the same results in neurons derived from human embryonic stem cells."

In 2011, this team of UC San Diego scientists discovered that more than one-third of the genes in the brains of mice are direct targets of TDP-43, affecting the functions of these genes. In the new study, they compared the impact of the FUS/TLS protein to that of TDP-43, hoping to find a large target overlap.

"Surprisingly, instead we saw a relatively small overlap, and the common RNA targets genes contained exceptionally long introns, or non-coding segments. The set is comprised of genes that are important for synapse function," said principal investigator Gene Yeo, PhD, assistant professor in the Department of Cellular and Molecular Medicine and the Institute for Genomic Medicine at UC San Diego and a visiting professor at the Molecular Engineering Laboratory in Singapore. "Loss of this common overlapping set of genes is evidence of a common pathway that appears to contribute to motor neuron degeneration."

In an effort to understand the normal function of these two RNA binding proteins, the scientists knocked down the proteins in brains of mice to mimic nuclear clearance, using antisense oligonucleotide technology developed in collaboration with ISIS Pharmaceuticals. The study resulted in a list of genes that are up or down regulated, and the researchers duplicated the findings in human cells.

"If we can somehow rescue the genes from down regulation, or being decreased by these proteins, it could point to a drug target for ALS to slow or halt degeneration of the motor neurons," said Yeo.

These proteins also look to be a central component in other neurodegenerative conditions. For example, accumulating abnormal TDP-43 and FUS/TLS in neuronal cytoplasm has been documented in frontotemporal lobar dementia, a neurological disorder that has been shown to be genetically and clinically linked to ALS, and which is the second most frequent cause of dementia after Alzheimer's disease.

###

The team was led by Gene Yeo, PhD and Don W. Cleveland, PhD, professor and chair of the UCSD Department of Cellular and Molecular Medicine and head of the Laboratory of Cell Biology at the Ludwig Institute for Cancer Research. Additional contributors include Anthony Q. Vu, Michael Baughn, Stephanie C. Huelga, Kevin M. Clutario, Shuo-Chien Ling, Tiffany Y. Liang and John Ravits, UC San Diego; Curt Mazur, Edward Wancewicz, Aneeza S. Kim, Andy Watt, Sue Freier and Frank Bennett, Isis Pharmaceuticals, Carlsbad, CA; Geoffrey G. Hicks, University of Manitoba, Winnipeg, Canada; and John Paul Donohue and Lily Shiue, UC Santa Cruz.

This work was supported by grants from the US National Institutes of Health (R37NS27036 to Cleveland and K99NS075216 to Polymenidou). Polymenidou is the recipient of a long-term fellowship from the international Human Frontier Science Program Organization. Lagier-Tourenne is the recipient of a Career Development Award from the Muscular Dystrophy Association and the Milton-Safenowitz post-doctoral fellowship from the Amyotrophic Lateral Sclerosis Association. D.W.C. receives salary support from the Ludwig Institute for Cancer Research. Huelga is funded by a US National Science Foundation Graduate Research Fellowship. This work was also supported by grant number R01NS075449 from the US National Institute of Neurological Disorders and Stroke, and was partially supported by grants from the US National Institutes of Health (HG004659 and GM084317) and the California Institute for Regenerative Medicine (RB1-01413 and RB3-05009) to Yeo. Yeo is a recipient of the Alfred P. Sloan Research Fellowship.



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Common RNA pathway found in ALS and dementia [ Back to EurekAlert! ] Public release date: 30-Sep-2012
[ | E-mail | Share Share ]

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego

Two proteins previously found to contribute to ALS, also known as Lou Gehrig's disease, have divergent roles. But a new study, led by researchers at the Department of Cellular and Molecular Medicine at the University of California, San Diego School of Medicine, shows that a common pathway links them.

The discovery reveals a small set of target genes that could be used to measure the health of motor neurons, and provides a useful tool for development of new pharmaceuticals to treat the devastating disorder, which currently has no treatment or cure.

Funded in part by the National Institutes of Health and the California Institute for Regenerative Medicine (CIRM), the study will be published in the advance online edition of Nature Neuroscience on September 30.

ALS is an adult-onset neurodegenerative disorder characterized by premature degeneration of motor neurons, resulting in a progressive, fatal paralysis in patients.

The two proteins that contribute to the disease FUS/TLS and TDP-43 bind to ribonucleic acid (RNA), intermediate molecules that translate genetic information from DNA to proteins. In normal cells, both TDP-43 and FUS/TLS are found in the nucleus where they help maintain proper levels of RNA. In the majority of ALS patients, however, these proteins instead accumulate in the cell's cytoplasm the liquid that separates the nucleus from the outer membrane, and thus are excluded from the nucleus, which prevents them from performing their normal duties.

Since the proteins are in the wrong location in the cell, they are unable to perform their normal function, according to the study's lead authors, Kasey R. Hutt, Clotilde Lagier-Tourenne and Magdalini Polymenidou. "In diseased motor neurons where TDP-43 is cleared from the nucleus and forms cytoplasmic aggregates," the authors wrote, "we saw lower protein levels of three genes regulated by TDP-43 and FUS/TLS. We predicted that this, based on our mouse studies, and found the same results in neurons derived from human embryonic stem cells."

In 2011, this team of UC San Diego scientists discovered that more than one-third of the genes in the brains of mice are direct targets of TDP-43, affecting the functions of these genes. In the new study, they compared the impact of the FUS/TLS protein to that of TDP-43, hoping to find a large target overlap.

"Surprisingly, instead we saw a relatively small overlap, and the common RNA targets genes contained exceptionally long introns, or non-coding segments. The set is comprised of genes that are important for synapse function," said principal investigator Gene Yeo, PhD, assistant professor in the Department of Cellular and Molecular Medicine and the Institute for Genomic Medicine at UC San Diego and a visiting professor at the Molecular Engineering Laboratory in Singapore. "Loss of this common overlapping set of genes is evidence of a common pathway that appears to contribute to motor neuron degeneration."

In an effort to understand the normal function of these two RNA binding proteins, the scientists knocked down the proteins in brains of mice to mimic nuclear clearance, using antisense oligonucleotide technology developed in collaboration with ISIS Pharmaceuticals. The study resulted in a list of genes that are up or down regulated, and the researchers duplicated the findings in human cells.

"If we can somehow rescue the genes from down regulation, or being decreased by these proteins, it could point to a drug target for ALS to slow or halt degeneration of the motor neurons," said Yeo.

These proteins also look to be a central component in other neurodegenerative conditions. For example, accumulating abnormal TDP-43 and FUS/TLS in neuronal cytoplasm has been documented in frontotemporal lobar dementia, a neurological disorder that has been shown to be genetically and clinically linked to ALS, and which is the second most frequent cause of dementia after Alzheimer's disease.

###

The team was led by Gene Yeo, PhD and Don W. Cleveland, PhD, professor and chair of the UCSD Department of Cellular and Molecular Medicine and head of the Laboratory of Cell Biology at the Ludwig Institute for Cancer Research. Additional contributors include Anthony Q. Vu, Michael Baughn, Stephanie C. Huelga, Kevin M. Clutario, Shuo-Chien Ling, Tiffany Y. Liang and John Ravits, UC San Diego; Curt Mazur, Edward Wancewicz, Aneeza S. Kim, Andy Watt, Sue Freier and Frank Bennett, Isis Pharmaceuticals, Carlsbad, CA; Geoffrey G. Hicks, University of Manitoba, Winnipeg, Canada; and John Paul Donohue and Lily Shiue, UC Santa Cruz.

This work was supported by grants from the US National Institutes of Health (R37NS27036 to Cleveland and K99NS075216 to Polymenidou). Polymenidou is the recipient of a long-term fellowship from the international Human Frontier Science Program Organization. Lagier-Tourenne is the recipient of a Career Development Award from the Muscular Dystrophy Association and the Milton-Safenowitz post-doctoral fellowship from the Amyotrophic Lateral Sclerosis Association. D.W.C. receives salary support from the Ludwig Institute for Cancer Research. Huelga is funded by a US National Science Foundation Graduate Research Fellowship. This work was also supported by grant number R01NS075449 from the US National Institute of Neurological Disorders and Stroke, and was partially supported by grants from the US National Institutes of Health (HG004659 and GM084317) and the California Institute for Regenerative Medicine (RB1-01413 and RB3-05009) to Yeo. Yeo is a recipient of the Alfred P. Sloan Research Fellowship.



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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-09/uoc--crp092712.php

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High-End Foreclosures ? Real Estate | Raw Business Law

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With 1 in every 483 households in the U.S. facing foreclosure, it only stands to reason that us common folk aren?t the only ones affected by the housing crisis. It?s just as easy to create a mountain of debt by borrowing against a multi-million dollar estate, as it is for a moderately priced home. Here are some of the celebrities added to the country?s growing list of foreclosures.

Sadly Ed McMahon, former Tonight Show announcer, is facing foreclosure for $4.8 million dollars of mortgage loans on his Beverly Hills estate. Plagued with bad press, this luxury home overlooking Coldwater Canyon and Mulholland Drive has been up for sale for $6.25 million for the last two years. Initially McMahon faced problems due to mold infestation which he claimed killed his dog and affected the health of both him and his wife. Then he fell and broke his neck and was out of work for 18 months. How would any of us deal with a back mortgage and loans totaling $4.8 million after being unemployed that long? Ed, take this as a sign, maybe it?s time to down size and retire.

Evander Holyfield, former heavyweight boxing champion is facing foreclosure on his Atlanta, Georgia estate. This 104-room, 54,000 square-foot home worth approximately $10 million, goes up for auction on July 1.

Jose Canseco, former major league baseball player recently lost his 7,300 square foot home in Encino to foreclosure. As he stated, ?It didn?t make financial sense for me to keep paying a mortgage on a home that was basically owned by someone else.? He didn?t mention how much the home was actually worth, but he owed the bank $2.5 million on the house.

Michael Jackson ? In 2007 after borrowing against it, to the tune of $23 million, the ranch valued at only $6 million faced foreclosure. Recently, however, a private equity group bought the loan on Neverland Ranch and is discussing the option of a Las Vegas casino gig as repayment.

In May of 2008, the $600,000 home of NBA star Latrell Sprewell went into foreclosure. This came only months after his 70-foot yacht, ?Milwaukee?s Best? was also repossessed. Sorry Latrell, maybe you shouldn?t have turned down the $21 million contract extension Minnesota offered you.

Grammy Award-winning Aretha Franklin received a notice of foreclosure against her Detroit mansion after failing to pay a $162.14 tax bill dating back to 2005. Last we heard, the bill was cleared up.

Veronica Hearst, step mother of SLA hostage Patty Hearst, faced foreclosure on her 28,000 square foot, 52-room villa in Palm Beach. Her defaulted mortgage payments totaled about $33,000,000. It?s hard to believe the deficit was allowed to get that high before the bank stepped in.

Nicole Murphy was unable to make payments on the 11,158 square foot mansion she was awarded in her 2006 divorce settlement from Eddie Murphy. Last October the house was put on the market for the bargain price of $6,500,000.

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Source: http://rawbusinesslaw.com/2012/09/29/high-end-foreclosures-real-estate/

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Personal Storage Ottawa Helps Free Up Space in Your Home Or ...











When it comes to freeing up space in your home, you need a company that offers personal storage ottawa services. Getting affordable personal storage is important when your home is either too small or far too cluttered to be comfortable. Personal storage Ottawa units allow you to store all of those items in a safe and secure environment. You don't have to worry about anybody accessing these items, since you will be able to lock the storage unit so that nobody can get to it. There a lot of benefits to owning a personal storage unit, below you will find some of the items that are useful to be stored in these containers.

Yard equipment We don't often mow or clean up our yards, so storing yard equipment in a personal storage unit is a great opportunity. If you have a lot of machinery like weed whackers, lawnmowers, tremors and more, storing this in your personal storage unit gets it out of your home and away from your sight. The best part about it is that storage units aren't really that expensive. In general, a typical storage unit will be well under $100 per month. This allows you to save money and get all of your garden equipment stored safely and securely in a unit that you can access when you need it. Anytime that you go to clean your yard, you can simply drive down to your unit and pick up your items.

A spare car Believe it or not, storage unit facilities will actually let you store a spare car inside one of their containers. Lots of people have spare cars around their home, but this can really take away from the overall appeal of your home. If you have a spare car that just sits in your front yard or driveway, you can store that car in a storage unit so that you no longer have to see it anymore. Surely, you and your neighbors are going to appreciate this opportunity.

Antiques Antiques can be something that we want to hold onto for as long as possible. Storing these antiques somewhere that they're going to be safe is important so that you can one day sell them and get a return on investment. If you have lots of antique furniture or items in your home, rather than keeping them in the garage or sitting somewhere that they really don't belong, you can store them in a storage unit. It doesn't matter what type of antiques you own, storage units will accept whatever it is you want to bring into the facility.

Business supplies Often times, businesses will have far too many supplies in order to keep all of them at their place of business. Additionally, if you operate out of your home, it can be difficult to keep track of business supplies and organize them efficiently. If you'd like a place to store some of the things that you purchase for your business, a storage unit is a great opportunity to do so.

Keywords: personal storage ottawa, ottawa storage, business storage, self storage ottawa

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Saturday, September 29, 2012

Practicing Yoga When Sick with Cold or Flu Can Aid Your Recovery

I am often asked if it is appropriate to practice yoga when sick with a cold or some sort of energy-zapping bug. Some experts are convinced that rest is the best medicine when not feeling well, but practicing a little bit of yoga when you are sick can be beneficial.

The following is an explanation of why yoga can help restore your health while you are fighting an illness.

Immune Boost

Yoga stimulates the immune system by flushing swollen lymph nodes and circulating white blood cells throughout the body. Gentle inversions such as downward dog help to create a small amount of pressure on the lymphatic system so fluids can flow freely and help the body fight infection.

The key point to remember is that too much yoga is not going to be beneficial. The body uses a lot of energy when it is sick, and stealing some of that energy so you can do a full yoga practice is not advised. Practice just a few poses, and make sure you have a lot of time to rest in between each pose. If your body is telling you to stop, honor its request and take a break.

Mood Enhancement

Feeling good physically is closely related to feeling good mentally and emotionally. Yoga helps both the mind and the body perk up and be cheerful. If feeling sick has snatched up your positive outlook, yoga poses that do not require a lot of energy, such as mountain pose or a seated spinal twist, are good choices to boost your mood. Just be sure and take it slow, because when you are sick a little bit will go a long way.

Detoxification

Toxins in the form of pathogens, a.k.a. germs, make us sick. It is up to our circulatory, excretory, and integumentary systems to help rid the body of these toxins. If our heart, kidneys, and sweat glands are doing their job, we can kick out these germs in no time.

Yoga stimulates all of the body?s systems. Rhythmic breathing, along with gentle movement, flushes our organs with oxygenated blood and nutrients. Stagnation only serves to delay the onset of healing, which is why it is important to keep the body moving and the body?s systems actively working.

As always, trust that your body knows best. Practice a few key poses with caution to stimulate your body, not to annihilate your health.

Also Read:

What Does the Color of Your Yoga Mat Mean?

Top 5 Foods to Prevent Cold and Flu

The Best Immune Boosting Foods

September 28th, 2012

Source: http://www.dietsinreview.com/diet_column/09/practicing-yoga-when-sick-with-cold-or-flu-can-aid-your-recovery/

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LA billionaire covets sports teams to promote health

LOS ANGELES (Reuters) - Bio-tech entrepreneur Patrick Soon-Shiong, the richest man in Los Angeles, intends to make a bid for sports and real estate firm Anschutz Entertainment Group and wants to bring a National Football League team back to the second most populous U.S. city.

The 60-year-old sports fan, a surgeon who started and sold two pharmaceutical companies for a combined $8.6 billion, told Reuters in an interview this week that he wants to use Anschutz concert tours and sports events, and his NFL team's players, to encourage L.A. school children to adopt healthier lifestyles.

"The NFL can do so much for this city," said Soon-Shiong in an interview at his west Los Angeles office. "Kids really rally around sports and entertainment and it could be a major catalyst to demonstrate what you can do in life by living better."

Soon-Shiong grew up in South Africa, where he became a doctor in his early 20s and treated tuberculosis victims. After moving to the United States and becoming a surgeon at UCLA, he developed innovative methods to treat diabetes and cancer patients.

The sale of his two companies for $8.6 billion made him the wealthiest person in Los Angeles, according to Forbes magazine, although he still is not a household name in the city.

Under his plan, players would serve as mentors, encouraging students to eat better and exercise more. The most sophisticated methods used to deal with sports injuries could be shared with local doctors.

"It's important to motivate students in middle and high school. That's when you can help reduce diabetes and obesity that cause illness," he said. "Maybe we can turn that illness to wellness."

If he's successful in L.A., Soon-Shiong said he intends to make it a national program.

FORMING INVESTMENT TEAM

Sources say the billionaire is assembling a group of other Los Angeles business and civic leaders to buy AEG. Soon-Shiong did not discuss details of his bid.

Sources also said his buyer group includes private equity firm Guggenheim Partners, which this spring led a group that bought the Los Angeles Dodgers baseball team for $2 billion.

AEG, which is owned by Denver billionaire Phil Anschutz, said on September 19 it had hired Blackstone Advisory Partners to sell the company. It is expected to fetch $6 billion to $8 billion, according to investment bankers with knowledge of its assets.

Separately, Los Angeles for years has wanted to bring back a professional football team, and Soon-Shiong acknowledged that he has met with the NFL to lay out his plan to buy a team.

AEG owns the Los Angeles Kings pro hockey franchise, the L.A. Galaxy soccer club and a 20 percent stake in the Los Angeles Lakers basketball team. It owns or operates sports and entertainment arenas worldwide, including the Staples Center in Los Angeles, and promotes concerts and other live action events.

Soon-Shiong's family foundation has committed $1 billion to transform healthcare and intends to create a national health superhighway by which doctors can share biotech information and other data to improve diagnosis and care.

His foundation gave $135 million to the Saint John's Health Center in Santa Monica and $100 million to reopen Martin Luther King Hospital, which serves lower income patients in south Los Angeles.

A basketball fan who played in pickup games until tearing his Achilles tendon three years ago, Soon-Shiong owns a 5 percent stake in the Lakers, and he said he has become friends with superstar Kobe Bryant and other players, whom he sees as role models for young fans.

In March, he and his actress wife, Michelle Chan, endowed the Chan Soon-Shiong Center for Sports Science at Saint John's, which will focus on sports medicine, physical therapy and stem cell research to help heal injuries.

It works with sports medicine doctors, including the Kerlan-Jobe Orthopedic Clinic that treats the Kings, Lakers and L.A. Dodgers.

Saint John's announced the sports science center at a dinner honoring AEG president Tim Leiweke in March, six months before Soon-Shiong showed his interest in the conglomerate.

(Editing by Peter Henderson and Jim Loney)

Source: http://news.yahoo.com/la-billionaire-covets-sports-teams-promote-health-110158087--nfl.html

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Friday, September 28, 2012

RolePlayGateway?

I'm checking the interest on dark fantasy. Angels, demons, vampires, werewolves, necromancers, gifted humans, and such.

I have a majorly long backstory that I wouldn't want to bore you with at the present time, but for the sake of conveying information, here's a basic outline:

-'Angels' are more like deities because their soul purpose is to travel between galaxies creating life on planets that can sustain it.
-When the angels created humans, they were different from their other prior creations because they didn't respect the land and the other humans.
-The angels leave, thinking that this problem would sort itself out (because angels can't destroy their own creations), but then return after several centuries to try again. Too bad for them, the humans are still alive and have deconstructed their planet to reconstruct it how they see fit. They're also fighting wars among each other.
-The second time around, they've brought a younger angel with them who can't understand why her angel brethren would just leave behind the humans in their misery. There must be something we can do...
-The other angels don't hear the young one, and in turn, the angel 'loses her innocence' and her heart is corrupt with dark energy, so she crashes into earth after her wings splinter away and turn the color of charcoal, losing her ability to travel through space and becoming the first Fallen Angel that this universe has seen.

-Upon testing her ability to create life, the fallen angel creates a shadow demon by the name of Umbrok.
-Shadow demons are tall, dark (bluish-tinted) skinned, red-eyed, sharp-teethed creatures who can take the form of a shadow/smoke.
-After conversing together, they decide that Velyssa, the fallen angel is right for believing the way humans act is wrong and that they need a sole ruler over them to keep them in check.
-Umbrok begins to recruit humans who are close to death (at first, only humans who have been nearly murdered by their own kind, but it doesn't take long to branch out to the sick, etc.).
-Umbrok brings said humans back to the angel who corrupts their souls and turns them into vampires: immortal, blood-thirsty, darkness-thriving creatures.
-Vampires can blend in with humans except for their pale skin and fangs. If they have fed recently, and can resist their urge to kill, then they won't have a problem being around humans for a while. Isolation and not drinking human blood makes them weak, and their weakness makes them intolerant of the sun. The sun and fire will return them to their normal 'human weaknesses', making them destroy-able. Set a vampire on fire, and it won't survive for long.
-Yes, I said vampires can blend in with humans, however, the corrupt soul within them makes them 'controllable' by the fallen angel, not to the extent where said vampires will do her bidding, but they will lose all of their inhibitions when the fallen so chooses, causing them to have no problem killing even their closest friends or relatives.

-After this first 'controlling' happens (I'll continue on referring to it as the 'blood oath'), it sends out a beacon of dark energy into the galaxies (due to a miscalculation on power needed to control these vampires by Velyssa) alerting the angels of the evil afoot.
-The angels return to see vampires beginning to pick off the human race bit by bit without any means to fight back, so they believe that it is their duty to give them power against these creatures.
-The angels seek out those who are pure of heart and grant them an ability that would help them defend themselves.

-Umbrok reports the angels and their happenings to Velyssa who further commands Umbrok to bring her those who seek power, but the angels hadn't given it to them.
-When Velyssa receives these humans, she removes the 'death-force' within their soul (corrupting it and making them controllable via the blood oath), leaving behind only their life-force making them further ageless and able to control the dead. These corrupted humans are known as necromancers and they typically lose their minds with power and infatuation for the dead.
-Let it be noted that a 'death-force' taken from a human doesn't simply disappear. Velyssa renders it into a demon of death.
-When the blood oath takes them over, the necromancers use their powers and they and the reanimated dead go on a mindless killing spree.

-Death demons are tall, like shadow demons, but their skin is completely white. Their hair is transparent, like fishing wire. Their eyes have lone, ghostly pupils within them. They look as if their made of simply skin and bones (no muscle). Wherever they go, they can absorb the life from around them, turning it into their strength/muscle. They can only teleport in their weakest form.

-Before the angels hear about the necromancers and death demons, they plan to take their leave. They can't remain on one planet forever.
-However, they mean to give future humans a chance to protect themselves, so they visit certain elders in certain regions and grant them the power to give abilities to other humans.
-Once the angels leave, humans begin swarming the elders and they have to check each visitor for purity of heart before they can grant them any power.
-Another setback would be that the elders have only a basic idea of how to use these abilities, and upon first attempts, it is perceived that a human might not have received any power, however, on the night of the first following full moon, these humans who were the rare anomaly to not receive power transformed into wicked creatures who killed and pillaged everything in sight until morning.

---

Well, that introduces the basis of the story line. Except that there is another, (I believe) final type of demon referred to as 'The Wicked'. They look just like humans, though some are known to have horns or wings, and they also have strange eye color (purple, red, dark green, etc.). They have no special abilities beyond being extraordinarily charming and persuasive. They look harmless enough, but their job is to take advantage of a human's sinful nature and send them to the brink of their destruction, so a shadow demon or death demon can recruit them to the fallen angel. They can pose as the perfect best friend or lover and make you develop habits and addictions that can break a person down.

Anyway, that's my story. I'm sorry it's so long. If you have any questions, I'd love to answer them.

Source: http://feeds.feedburner.com/RolePlayGateway

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A Cancer Patient's Best Friend - NYTimes.com

Life, Interrupted

Suleika Jaouad writes about her experiences as a young adult with cancer.

When I was growing up, my dream was to one day become a veterinarian. In fourth and fifth grade, I volunteered every day after school at a veterinarian?s clinic. I didn?t view it as an ?internship? ? in my mind, I was apprenticing for a certain future in the field. When I was 10, I asked for an incubator for Christmas. By spring, I was carting around a dozen baby chicks in my purple doll stroller. In middle school I walked dogs at the local animal shelter. But as I got older, there was college, summer travel, then my first real job, at a law firm in France. I was entering the ?real world,? as they say in commencement speeches. And there was no room in my adult life for a dog.

Then, a year and a half ago, came my cancer diagnosis, and with it the return home. I found myself pleading with my parents for a puppy, just as I?d done as a child. But I knew the medical reality: My weakened immune system, the result of chemotherapy, made getting a dog impossible. My doctors didn?t even think twice about rejecting the prospect, though I still made it a point of asking every few months.

In early September, I was shocked when I received a voice mail message from one of the nurses in the bone marrow transplant clinic. Instead of rescheduling an appointment or changing the dosage of one of my medications, she had dog-related news: My doctors had decided to give me the green light on adopting a furry friend. In fact, they encouraged it. My immune system was stronger ? not as strong as it could be, but relatively strong for a patient in the first six months after transplant. And caring for a pet, my doctors told me, might even be therapeutic. As a cancer patient, I?m always being prescribed medicine. But I never thought I?d get a prescription for a puppy.

I didn?t waste much time. The same day I headed with my boyfriend, Seamus, to Animal Haven, a rescue animal organization in Lower Manhattan. As we skimmed their selection of dogs, I began to feel overwhelmed. There were big dogs and small ones, old and young. How could I pick my future companion as if I were shopping for shoes in a catalog? But when I saw Schnoodle, a 9-week-old miniature schnauzer and toy poodle mix with big brown eyes, floppy puppy ears and soft white fur, I couldn?t resist. I didn?t need to see any other dogs. I knew I had to bring him home. In the cab ride home, ?Schnoodle? became ?Oscar,? named after my favorite writer, Oscar Wilde, and Seamus?s favorite basketball player, Oscar Robertson.

I?m giddy these days since Oscar came into my life. Caring for a pet is a welcome distraction from the day-to-day reality of being a cancer patient. I?m not sure what it is about puppies, but holding Oscar instantly makes me feel better. I?ve had him for only 13 days, but my new favorite pastime is to watch him sleep, his tiny black paws twitching as he chases rabbits in his puppy dreams. The warmth of his little body and the steady beat of his heart against my chest distract me from my anxiety. He brings me instantly to the present.

In the short time Oscar has been in my life, he?s had an effect on my relationships. Rather than staring at my bald head, passers-by stop to play with Oscar and to tell me how cute he is. The other tenants in my building now say hello to my dog before greeting me. And instead of discussing my symptoms and treatment plan for the week, my boyfriend and I have been spending more time focused on puppy playtime, going on long walks in the park and taking Oscar to his obedience classes. It?s nice not to be the center of attention for a change.

But the reality is that I am a cancer patient. I have to take extra health precautions, like wearing gloves when I clean up after him and washing my hands thoroughly. It?s work, but I enjoy the structure, something cancer patients often lack. I share responsibility for Oscar with my boyfriend, which allows me to rest when I need to.

For now, I?m in a tenuous type of remission reserved for ?high risk? leukemia patients in the first year after transplant. I still feel anxious at each appointment, as I wait to hear that the previous week?s test results are all right. I still take medicine (23 pills a day, by my last count). I still have my weekly appointments at the hospital. And every three weeks, I do a five-day course of preventive chemotherapy.

But it?s a sign of my progress that I?m allowed to be around a dog at all. My immune system is getting stronger, my doctors tell me. Oscar can?t change what?s going on in my bone marrow. But I can feel that he?s already working magic.


Suleika Jaouad (pronounced su-LAKE-uh ja-WAD) is a 24-year-old writer from Saratoga Springs, N.Y. Her column, ?Life, Interrupted,? chronicling her experiences as a young adult with cancer, appears weekly on Well. Follow @suleikajaouad on Twitter.

Source: http://well.blogs.nytimes.com/2012/09/27/a-cancer-patients-best-friend/

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Live?from the Built Green Conference 2012: Keynote Speaker Denis

Wow what a great lunch

King County Green Tools staff Patti Southard and Kinney (missed the other name) made introductory remarks for Mr. Hayes. First they gave us some statistics and diversion rates for construction materials. Newest edition of the Construction Recycling Directory just came out. He suggests that builders use 2 bins on sites so the sorting is done immediately because it is very time consuming to sort it later. He also mentioned the 20/20 Refit Challenge. Rehabilitating older homes to become healthy, comfortable, energy efficient homes is a lot more sustainable than deconstructing a structure and building something new It?s all about keeping materials out of the waste stream.

Patti thanks the staff at Built Green for creating such a great model that others in the country look to. Collaboration is key. She says every day we are working on making this a beter planet it is like writing a love letter to the Earth. She says we are lucky to have the kind of leadership we have in our area ? with Denis Hayes, the founder of Earth Day, having joined our community. She shared her own memories of how Earth Day is a holiday not for religion or anything else, but for doing something for others and the plant.

Denis Hayes
Funny guy! Seems to be speaking extemporaneously. He said normally he gives a rousing motivational speech about becoming more green. But he doesn?t have to do that here, since everyone in the room is involved in the green building industry. He talked about how the Bullitt Foundation stat=started out in a hayloft, and since joining the organization the Board agreed to the construction of a green building. The piece of property the foundation owned called for something larger than an office for seven people, and now they have a 52,000 sq ft mixed use building. Billed as ?The Greenest Building in the World? He said there are 26 geothermal wells that are 400 feet deep. ALL of the energy that will be used in this building will be generated by the building. Net Zero is not accomplished very often. Hayes talked about trying to meet the requirements of the Living Building Challenge. He spoke about sourcing materials for the building, finding contractors who would

Bullitt Center ? Hard costs up through TI: 17% more expensive than regular Class A office space and found they can?t rent it for any more than regular Class A office space. If you are a tenant in their building and meet ll of your energy goals, you have no energy costs, it?s free. Society needs to start placing real value on things that endure. These major investments count for something. He talked a lot oabout the features that went into this new building. I missed the last tour a couple weeks ago! So I sent an email to find out when the next tour will be. Defnitely have to get it on it.

If I had to do it gain knwoing what I know now and this will sound ridiculous ? this is the first time I have worked on a building, but it has given me a lot of humility. So he deerred t a lot of te experts, vendors, and contractors, for elements and aesthetics that if he woudl have won on if he had stuck to his guns. And he would hold out to have it his way next time.

Wendy Hughes-Jelen is a Seattle-area Realtor? who is EcoBroker Certified? and is a Earth Advantage? Broker AND Built Green? Certified Professional. She helps people find and create their own healthy home, and is trained to assist those with chemical sensitivities, asthma, allergies, or other health concerns that indoor air quality can impact. Wendy is certified to use Energy Star's Portfolio Manager for Energy Efficiency Accounting and Benchmarking (NRGbenchmarking.com). Be sure to look for Westside Green Living With Wendy on Facebook.

Source: http://greenspacesrealestate.com/?p=1586

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Speaking Out about Public Speaking | The Two River Times

By Nancy Wade

Most high school students would recognize the plea of ?Friends, Romans, countrymen, lend me your ears,? as those immortal words from Shakespeare?s tragedy Julius Caesar. When the character of Marc Antony speaks out, he uses the power of rhetoric that so distinguished educated leaders of that era. So connected were the idea of discourse in a public forum to the idea of public advocacy and justice in the courts, that the Latin word forum ultimately gave rise to the term forensics, which today can mean both evidence used in courtrooms and,?alternately, a variety of public-speaking genres.

Today?s students no longer need to travel to the stone steps of a public forum to make their voices heard. Technology now allows them to make public statements from the confines of their own bedrooms. And with tools such as Skype, iChat, videoconferencing and YouTube, students are delivering their messages to increasingly larger audiences than ever before.

The irony of this development is that, as the opportunities for students to voice their ideas have escalated dramatically during the 21st century, public speaking programs in many schools have diminished drastically.

The ancient Romans and Greeks understood that public speaking was a powerful communication tool for effective leadership, motivation, influence and persuasion. At the highest points in these venerated civilizations, the finest education available included the study of rhetoric, which meant the composing and delivery of speeches. In fact, the Roman scholar Cicero refined the concept even further, espousing that a good public speaker required more than knowledge of his topic; he needed ethos, wit and the ability to keep his audience entertained.

Throughout the Middle Ages and during the Renaissance, public speaking, known as oratory, remained an integral part of a liberal arts education. After a decline in the 17th and 18th centuries, there was renewed interest in the art of public discourse during the 19th century. This revival made the art of oratory an increasingly important part of the curriculum in schools in the late 1800s. As a result, oratorical competitions became de rigueur in colleges, high schools and elementary schools across the land as educational institutions celebrated and promoted the forensics arts.

The value placed on oratory was evidenced at institutions of higher learning across our nation. Princeton University held numerous speech competitions, especially ones associated with patriotic events such as Washington?s birthday or other historic remembrances. At Harvard, oratory was a required and popular part of the curriculum for many years. One?s education was simply considered incomplete without it. The popularity of oratorical contests was noted in the New York Evening Post in February 1895 when an article on the subject stated that at the University of Indiana, ?oratory was more popular than sports.?

The 20th century emphasis on science and technology created an American culture that became less willing to finance programs in public speaking, and the word ?oratory? became part of our past, an old-fashioned term for a truly lost art. While many schools today no longer fund oratory as a curriculum area, a good number of schools continue to validate those critical?public speaking skills through extracurricular activities.

Forensics programs in some schools, for example, foster the growth of public speaking skills through interscholastic competitions. With the challenging budgets facing most schools today, these types of activities, if they exist at all, tend to be relegated to our high schools, leaving most elementary school students without formal training in public speaking until they reach the upper grades.

Teachers in elementary and middle school often work hard to include public-speaking opportunities for students in their classrooms, but the classical emphasis on oratory as an integral part of the educational process has ?become a thing of the past in most elementary schools.

The incongruity of this fact is obvious when we observe how many elementary and middle school students are expressing their opinions, thoughts and feelings on the Internet. ?With so many new digital platforms at their fingertips, students now have the power to have their voices heard around the world, and many educators will, hopefully, re-examine priorities regarding curriculum in the 21st century.

Students today more than ever before in history need the rhetorical skills that were once held in such high esteem in the classroom. Those 19th-century theories of elocution taught critical rhetorical skills that allowed students to form arguments and defend them, delivery skills like articulation and pacing, non-verbal communication skills like use of hands, eyes, and facial expressions, and, most of all, the ability to?connect with one?s audience through ethos.

We have given our students the tools needed to talk to others around the world through technology. Creating a curriculum for ?digital? oratory would now help students develop the forensics skills they need to use these new platforms to their best ability.

If Shakespeare were writing Julius Caesar today, he might very well have said, ?Friends, Romans, citizens of the world, lend me your ears.? Students in the 21st century are part of the global classroom and teaching them how to express their thoughts effectively through public speaking programs is now, more than ever before, part of our charge as their mentors.

?

Nancy Wade teaches the award-winning forensics program?at Ranney School in Tinton Falls. Since its inception in 1994, the Ranney Middle School Forensics Team has garnered?338 awards at various forensic competitions and venues throughout New Jersey;?116 of these award winners took?first place in their category.

Source: http://trtnj.com/letters-commentary/speaking-out-about-public-speaking/

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Thursday, September 27, 2012

Kingston Digital SDXC cards arrive with lower price, larger capacities

Kingston Digital SDXC cards arrive with low price, Class 10 speeds

Kingston's unveiled two new SDXC cards for anyone looking to upgrade the capacity (or performance speed) of their current removable storage of choice without denting the bank balance too much. The SDXC Class 10 cards arrive in 64GB and 128GB sizes, and Kingston reckons they'd go great with your new digital camera -- as long as it's compatible with the SDXC format, naturally. Both are available to buy now, direct from the storage manufacturer, alongside smaller capacities, with the 128GB card priced at $182 and the 64GB setting you back $80. The full press release is after the break.

Continue reading Kingston Digital SDXC cards arrive with lower price, larger capacities

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Kingston Digital SDXC cards arrive with lower price, larger capacities originally appeared on Engadget on Thu, 27 Sep 2012 20:05:00 EDT. Please see our terms for use of feeds.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/k6b-2rEm7lA/

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Streams Of Water Once Flowed On Mars; NASA Says Photos Prove It

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    Curiosity, 2012: NASA says that water shaped the rocks on the left, in a photograph taken by the Mars rover Curiosity. For comparison, the agency released an image of rocks from the Earth (right).

    NASA

  • Hide caption

    Curiosity 2012: A wider view of the outcrop of a former streambed shows bedrock that scientists believe was likely exposed by meteorites striking the surface of Mars.

    NASA

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    Spirit, 2010: When NASA's Spirit rover got stuck in Martian sand, it proved to be a lucky break: The spinning wheel churned up soil that provided evidence of rocks formed in the presence of water.

    NASA

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    Opportunity, 2004: Opportunity discovered tiny mineral spheres ? nicknamed blueberries ? poking out of rocks that were likely formed by water. Researchers using Opportunity's science instruments identified them as concretions rich in the mineral hematite, deposited by water saturating the bedrock.

    NASA

  • Hide caption

    Pathfinder, 1997: The first mission to land a rover on Mars, Pathfinder touched down in Ares Vallis, an ancient flood plain in the planet's northern hemisphere. Among the 2.3 billion bits of data sent back by the lander and its rover, Sojourner, were 15 chemical analyses of rocks and soil, which suggested Mars had once had liquid water and a thicker atmosphere.

    NASA

NASA's Curiosity rover has found definitive proof that water once ran across the surface of Mars, the agency announced today. NASA scientists say new photos from the rover show rocks that were smoothed and rounded by water. The rocks are in a large canyon and nearby channels that were cut by flowing water, making up an alluvial fan.

"You had water transporting these gravels to the downslope of the fan," NASA researchers say. The gravel then formed into a conglomerate rock, which was in turn likely covered before being exposed again.

The agency's scientists presented their findings of the former streambed on Mars at a news conference today.

"A River Ran Through It," Curiosity's operators tweeted Thursday. "I found evidence of an ancient streambed on Mars, similar to some on Earth."

"From the size of gravels it carried, we can interpret the water was moving about 3 feet per second," said Curiosity science co-investigator William Dietrich, "with a depth somewhere between ankle and hip deep."

The rocks have not undergone scientific analysis. But the NASA team says that taken with geographic data from Mars orbiters, the photographs tell a story all their own.

?

The images show rocks with round, smooth surfaces; many of them have been broken down into sizes smaller than one inch in diameter.

"The shapes tell you they were transported and the sizes tell you they couldn't be transported by wind," co-investigator Rebecca Williams said. "They were transported by water flow."

"There is earlier evidence for the presence of water on Mars," the agency said in a press release, "but this evidence ? images of rocks containing ancient streambed gravels ? is the first of its kind."

NASA's team has named the rock outcrop that reveals the former streambed "Hottah," after Canada's Hottah Lake.

Scientists have not yet estimated the age of the rocks, which may have been buried beneath the surface. Their age could be several billion years.

The next step will be to find a good spot to drill into the rock, NASA says. And they'll be looking for possible carbon deposits, to determine whether the water on Mars once supported life.

The photographs released Thursday are among more than 13,000 raw images Curiosity has captured. The rover took the photos during its mission to Mars' Gale Crater. The rocks in question lie between the crater's north rim and Mount Sharp, a mountain inside the crater.

NASA investigators presented the results of their analysis at NASA's Jet Propulsion Laboratory in Pasadena, Calif. You can read other posts about Curiosity in our archive.

Source: http://www.npr.org/blogs/thetwo-way/2012/09/27/161896238/streams-of-water-once-flowed-on-mars-nasa-says-photos-prove-it?ft=1&f=1007

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Richie Sambora's in "Good Place" with Heather Locklear

Time has been kind to exes Richie Sambora and Heather Locklear.

Source: http://www.ivillage.com/richie-sambora-im-very-good-place-ex-heather-locklear/1-a-490011?dst=iv%3AiVillage%3Arichie-sambora-im-very-good-place-ex-heather-locklear-490011

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Wednesday, September 26, 2012

Japan Passes Jail-for-Downloaders Anti-Piracy Law


Japan?s legislature has approved a bill revising the nation?s copyright law to add criminal penalties for downloading copyrighted material or backing up content from a DVD. The penalties will come into effect in October.

The Upper House of the Japanese Diet approved the bill by a vote of 221-12, less than a week after the measure cleared the lower house with almost no opposition. Violators risk up to two years in prison or fines up to two million yen (about $25,000).

Opponents of the bill worry it will lead to unnecessary prosecutions because of the way it is written. To face charges, a person must be aware that the material is illegal to download.

?We shouldn?t risk making the general public ? including youths ? the subject of criminal investigations,? said Upper House member Yuko Mori, as quoted in the Japan Times.

Japanese attorney Toshimitsu Dan told IT Media that even watching a YouTube video could be grounds for arrest ?if the viewer is aware that downloading [such material] is illegal.?

Unauthorized uploading and downloading of copyrighted material such as music, movies and video games have been illegal in Japan for years, but until now only uploaders were subject to criminal penalties: up to 10 years in prison or fines as much as 10 million yen ($125,000), according to the Times.

Source.

Pretty old bit of news, but I couldn't find it anywhere in arama, so just thought I'd post FYI.

Source: http://aramatheydidnt.livejournal.com/4303425.html

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Celebrating Shel Silverstein's Birthday and His Wacky Humor | Neon ...

Source: http://www.colesdistrict.org/personal-property-taxes-due-by-october-5/

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Tuesday, September 25, 2012

Apple TV update 5.1 brings shared photo streams and iTunes account swapping, available now

Apple TVs of the second and third-gen variety are getting update 5.1 today, which brings two long-awaited features. Both shared photo streaming and iTunes account switching are now part of Apple's set-top box -- the combination of those two finally freeing parents from the potential nightmare of discovering their child's "not safe for parents" photo streams, of course. The update, spotted by MacRumors, also adds some new AirPlay functionality, enabling users to "send audio content from Apple TV to AirPlay-enabled speakers and devices (including AirPort Express and other Apple TVs)." Beyond those two biggies, however, the rest of the update is rather nuts and bolts oriented -- head below for the full list.

Continue reading Apple TV update 5.1 brings shared photo streams and iTunes account swapping, available now

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Apple TV update 5.1 brings shared photo streams and iTunes account swapping, available now originally appeared on Engadget on Mon, 24 Sep 2012 14:12:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/09/24/apple-tv-update-5.1/

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Video: Bob Doll's Market Plan: Stay With Stocks

Sorry, Readability was unable to parse this page for content.

Source: http://video.msnbc.msn.com/cnbc/49146292/

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Running A Small Business Server With ClearOS 6.3.0 (Community ...

Version 1.0
Author: Falko Timme <ft [at] falkotimme [dot] com>
Follow me on Twitter
Last edited 09/24/2012

This guide shows how you can install and run a Small Business Server with ClearOS 6.3.0 (Community Edition). With ClearOS, you can run various services (such as a file- and print server, a web proxy and content filter, a mail server, etc.) in your local network and manage them through an easy web interface. ClearOS provides apps for each of these tasks from its marketplace - many of them are free, some of them have to be paid for. ClearOS Community is open-source and free. There's also a professional version available for which you have to pay, but which in return provides better support, better tested apps and updates, etc.

I do not issue any guarantee that this will work for you!

?

1 Preliminary Note

In this tutorial I use the hostname server1.example.com with the IP address 192.168.0.100. These settings might differ for you, so you have to replace them where appropriate.

ClearOS is based on RHEL/CentOS, so you might be familiar with its installer already.

?

2 Installing ClearOS 6.3.0

Download the ClearOS 6.3 Community ISO image from http://www.clearfoundation.com/Software/downloads.html, burn it onto a CD, and boot from it. Select Install or upgrade an existing system:

The welcome screen of the ClearOS installer appears. Click on Next:

Choose your language next:

Select your keyboard layout:

I assume that you use a locally attached hard drive, so you should select Basic Storage Devices here:

You might see the following warning - The storage device may contain data. If you see this click on the Yes, discard any data button to proceed:

Fill in the hostname of the server (e.g. server1.example.com), then click on the Configure Network button:

Go to the Wired tab, select the network interface (probably eth0) and click on Edit...:

Mark the Connect automatically checkbox and go to the IPv4 Settings tab and select Manual in the Method drop-down menu. Fill in one, two, or three nameservers (separated by comma) in the DNS servers field (e.g. 8.8.8.8,8.8.4.4), then click on the Add button next to the Addresses area. Now give your network card a static IP address and netmask (in this tutorial I'm using the IP address 192.168.0.100 and netmask 255.255.255.0 or 24 for demonstration purposes; if you are not sure about the right values, http://www.subnetmask.info might help you). Also fill in your gateway (e.g. 192.168.0.1) and click on the Apply... button:

The network configuration is now finished. Click on the Next button:

Choose your time zone:

Give root a password:

Next we do the partitioning. Select Replace Existing Linux System(s). This will give you a small /boot partition and a large / partition which is fine for our purposes:

Select Write changes to disk:

The hard drive is being formatted, and the installation begins. This will take a few minutes:

Finally, the installation is complete, and you can remove your CD from the computer and reboot it:

After the first reboot...

... you will see the following screen which tells you to use a browser to configure ClearOS and which URL to use to connect to the ClearOS web interface (https://192.168.0.100:81 in this case):

Running A Small Business Server With ClearOS 6.3.0 (Community Edition) - Page 2


Source: http://www.howtoforge.com/running-a-small-business-server-with-clearos-6.3.0-community-edition

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